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Combination therapy with CoQ10 (1% of feed) and creatine (2% of feed) exert additive protective effects in an animal model of Parkinson's ( MPTP toxicity) and Huntington's disease ( 3-nitropropionic acid toxicity) with combination therapy reducing the lesion sizes to 17% (3-NP) and attenuating the dopamine loss from MPTP from 56% to 13%.

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