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The systemic administration of quinolones, including ofloxacin at doses much higher than given or absorbed by the otic route, has led to lesions or erosions of the cartilage in weight-bearing joints and other signs of arthropathy in immature animals of various species.

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It works to lower eye pressure by decreasing the fluid production in the eye and by increasing the drainage of fluid out of the eye.

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It can be used in in older adolescents and adults to suppress ACTH production.

In patients with dense cataracts that preclude adequate visualization of the fundus, a Maddox rod test can be used to grossly evaluate macular function with detection of a large scotoma, represented as a loss of the red line, a sign suggestive of a macular pathology.

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Abuse of the drug may lead to moderate or low physical dependence or high psychological dependence.

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